5502
Ayman Mohamed Kamal Mostafa El-Sayed
Synthesis And Functionalization Of Biomedically Relevant Porphyrins
Porphyrins, Synthesis,for Photodynamic therapy , cancer
Herein, we synthesized a series of amphiphilic porphyrin derivatives 202a-d and 203 based on Temoporfin analoge (Foscan®) ─the 2nd generation photosensitizer drug as shown in (Scheme 1). Compounds 202a-d and 203 consist of porphyrin cores that were functionalized by three α-D-mannose units 199 as hydrophilic part and lipid unit 192a-d as hydrophobic part to mimic the living cell. Combination of these two parts in one molecule is defined as amphiphilic structure which has hydrophilichydrophobic balance and is preferable for uptake by tumor for Photodynamic therapy (PDT). The sugar units enhance the water solubility of the porphyrin photosensitizerbased drug as well as selective targeting of the lectin receptors that are over-expressed on the tumor surface. Meanwhile, the lipid part increases the uptake of the porphyrin core by the surface cell membrane
2018
Ph.d
Mansoura
Science