5660
Ahmed Sayed Ismail Aly
Assessment of Chemerin and Apelin levels as potential predictors for Vascular Endothelial Function in Obese Children
Obese children,Chemerin ,Apelin,Inflammation,Endothelial activation
.hs-CRP
Background: childhood obesity is now forming a global threat with subsequent health problems among which and most important is cardiovascular problems. It is now claimed that adipokines secreted by adipose tissue are responsible for such consequences. Newly discovered adipokines Chemerin and Apelin are under investigation for their link with obesity related co-morbidites.Aim: assessment of serum Chemerin and Apelin levels in a sample of Egyptian obese children and to determine the relationship between them with markers of inflammation and vascular endothelial cell activation in attempt to predict the risk for cardiovascular diseases in these children. Method: This comparative cross-sectional study was conducted on 45 obese subjects (BMI ≥ 95th percentile) aged from 6 to 11 years recruited from Diabetes Endocrine and Metabolic Pediatric Unit at Cairo University Pediatric Hospital and Medical and Scientific Centre of Excellence, National Research Center compared to 45 healthy children age and sex matched . General examination, anthropometric assessment (weight, height, waist circumference, and hip circumference), and laboratory tests (Endothelial activation molecules ( E-Selectin and ICAM-1),Chemerin, Apelin, lipid profile and hs-CRP) were done. Results: Serum Chemerin and Apelin levels were significantly higher in obese compared to non obese children. On correlating Chemerin and Apelinwith anthropometric parameters among obese subjects it showed no significant correlation.Interestingly there was a significant oncorrelati in the whole group when correlating Chemerin and Apelin with anthropometric parameters .On correlating Chemein and Apelin with Lipid profile and measures of inflammation (hs-CRP ) only Chemerin showed significant correlation in both obese and whole group while Aplein only showed a significant correlation in the whole group. No correlation was found between Chemrin and Apelin with Systolic BP zscore andDiastolic BPz score neither in the obese nor in the whole group. Moreover, we identified significant association between Chemerin and Apelin with the markers of endothelial activation (ICAM-1 and E-selectin) in the whole group but not in the obese.Multiple regression analyses confirmed that both Chemerin and Apelin are predictors for hs -CRP, ICAM-1 and E-selectin independent of BMI z score, age and sex. Conclusion: Our results showed an elevated serum level of both Chemerin and Apelin in obese children and suggest a possible correlation of Chemerin and Apelin with inflammatory (hs-CRP) and endothelial activation markers(ICAM-1 and E-selectin).
2020
Ph.d
Ain Shams
Medical research institute