5470
Mahmoud Afify Sayed Afify
Assessment of Gonadotropins and Androgens among
Pubertal Overweight and Obese Girls
Gonadotropins, androgens, pubertal girls, overweight, obesity
Background: Previous studies have suggested an association between adiposity, androgens and gonadotropins in late pubertal girls. Aim: Assessment the levels of gonadotropins and androgens among pubertal overweight and obese girls. Subjects and Methods: It was a cross-sectional one, carried out in the Obesity Clinic of the Diabetes, Endocrine and Metabolism Pediatric Unit (DEMPU), Pediatric Hospital, Cairo University and "Management of Visceral Obesity and Growth Disturbances Unit" at the "Medical Research Excellence Center (MERC)", National Research Centre. It included 40 overweight and obese girls and 40 age-matching normal weight (control) girls, aged 12 -18 years. Anthropometric assessment (weight, height, hip and waist circumferences) was recorded, BMI and waist/hip were calculated. Laboratory investigations: serum gonadotropins (LH, FSH) and androgens (total and free testosterone) were measured. Results: hypogonadotropism (FSH and LH) and hyperandrogenaemia (total and free testosterone) were significantly prominent among obese girls. Correlation between gonadotropins (FSH and LH), androgens (total testosterone and free testosterone) and all the studied variables for the 3 groups under study (control, overweight and obese) revealed constant relations. Gonadotropins and androgens had opposing correlations. Gonadotropins had significant negative correlations, and androgens had significant positive correlations with the anthropometric obesity markers defined as BMI, Waist C, and W/H ratio. In addition, gonadotropins and androgens had insignificant correlation with age. Conclusion: Obese girls had hypogonadotropism and hyperandrogenaemia. The changes in androgen levels were earlier than in gonadotropins among the overweight and obese girls. The correlations between gonadotropins and androgens in one side and the anthropometric measurements on the other side were the same in both overweight and obese girls.
2018
Ph.d
Ain Shams
Medicine