5123
Mona Abdullah Abdullaziz Mahmoud
Design and Synthesis of New 2-Furylbenzimidazoles of Expected Pharmacological Activity
Furylbenzimidazoles,vegfr2, mcf7, hepg2
The present investigation deals with the design, synthesis, in vitro antiproliferative activity, against MCF-7 and HEPG-2 cancer cell lines, and VEGFR2 inhibitory activity of certain newly synthesized 1-substituted 2-furylbenzimidazoles and 1-substituted 5-methyl 2- furylbenzimidazoles. Molecular docking of the synthesized compounds on the binding site of VEGFR2 and QSAR studies were also described.
2015
M.Sc
Cairo
Pharmacy