5095
Rasha Mohamed Mohamed Hassan
Synthesis and Anticonvulsant Evaluation of Some Substituted-1,3-Diazaspiro decan-4-one Derivatives
Synthesis, anticonvulsant, 1,3-diazaspirodecan-4-one derivatives
The search for anticonvulsant compounds with selective activity and less toxicity continues to be an area of intensive research in medicinal chemistry. Thus, in this work, the first part deals with the synthesis of certain substituted spiroimidazolidinones (1,3-diazaspiro[4.5]decan-4-ones) VIa-d and VIIIa-x and evaluation of their anticonvulsant properties. Also, in this part a molecular modeling study was performed for the designed target compounds. Moreover, in the second part, the enantioseparation of the racemic derivatives VIc-d and VIIIm-x using different polysaccharide type chiral stationary phases (CSPs), namely, Chiralcel OJ, Chiralcel OD and Lux –amylose-2 has been studied.
2015
Ph.d
Cairo
Pharmacy