5692
Gina Huessin Ahmed Ahmed Elpatrik
Efficacy of Vitamin D Supplementation on
Bone Mineral Density and Vitamin D
Binding Protein in Children with Autism
Vitamin D, autism spectrum disorder, vitamin D binding protein,
Dual Energy X-Ray Absorptiometry
Background: Autism spectrum disorder is a neuro-developmental disorder, which is reported to affect 1 in 59 children. Social communication deficits and restricted or repetitive interests and behaviors are main characterizing features. It is caused by the interaction of both genetic and environmental factors. Objective: To assess vitamin D, Vitamin D Binding Protein (VDBP) and bone mineral density in autistic children, compared to typically developing children, In addition to question the benefit of using oral vitamin D daily supplementation for 4 months on autistic children’s outcome. Patients and Methods: The study was conducted on 30 autistic patients recruited from the Autism Disorders Clinic, Medical Research Centre of Excellence, National Research Centre with age ranging from 3-7 years. Patients were randomly supplemented by vitamin D in a dose of 600 IU/day for 4 months. Thirty healthy children were included as controls, with matched age and socioeconomic status to the study group. Vit D assessment was done using blood samples, VBBP was assessed using ELISA. Moreover, DEXA was done over femur neck and lumber regions.
2020
Ph.d
Ain Shams
Institute of post graduate childhood studies