5079
Nahed Abd Elmordy Mashhout
Paracetamol versus indomethacin and ibuprofen administration in management of patent ductus arteriosus in premature infants
Patent ductus arteriosus - intravenous - paracetamol - Premature infants
The objectives: This study was to determine the efficacy and safety of intravenous paracetamol in closure of hemodynamically significant PDA in premature neonates in comparison to ibuprofen and indomethacin. Subjects and methods: The study included 40 premature infants ≤ 36 weeks gestational age admitted to Kasr Al-Ainy hospital, NICU units, Cairo University between October 2013 and August 2014 whom had clinically significant PDA. Results: 20 cases received intravenous paracetamol . 17 had their PDA closed after 1st course with closure rate of 85%, 3 cases received 2nd course, 2 of total 3 infants had their PDA closed with closure rate of 10%.10 cases received oral ibuprofen 8 had their PDA closed after 1st course with closure rate of 80%, 2 cases received 2nd course, one case had PDA closure with closure rate 10% and 10 cases received intravenous indomethacin 7 had their PDA closed after 1st course with closure rate 70%. 3 cases received 2nd course, 2 cases had PDA closure with closure rate 20%. Monitoring of hepatic functions pre and post treatment showed no significant adverse effects related to treatment. Conclusion: Intravenous paracetamol is safe and effective in treatment ofhaemodynamically significant PDA in premature infants.
2015
M.Sc
Cairo
Medicine