5063
Salma Ahmed Salah El Marasy
THE POSSIBLE ANTI-DEPRESSANT EFFECT OF CERTAIN NATURAL PRODUCTS IN DIABETIC RATS
NATURAL PRODUCTS / ANTI-DEPRESSANT / DIABETIC RATS
Diabetes mellitus (DM) is a chronic metabolic disorder characterized by hyperglycaemia, which may result from defects in insulin secretion, or insulin resistance (impaired response to insulin). Diabetic patients have a nearly 30% higher risk for depression than the general population. It has been documented that chronic hyperglycaemia promotes free radical accumulation that, in turn, results in inflammation. Increased levels of pro-inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha , have been reported to play a dual role, in the development of diabetes as well as depression. Many studies demonstrated the importance of neurotrophins, especially the brain derived neurotrophic factor (BDNF), in the pathophysiology of diabetes as well as depression. DM is also accompanied by alterations in brain monoaminergic neurotransmitters, namely, norepinephrine (NE), dopamine (DA), and serotonin (5-HT), which can result in depression. Although classical anti-depressants are recommended as the first-choice drugs for treatment of depression associated with diabetes, through restorationof brain monoamines, mainly NE and 5-HT, animal and human studies have shown that they can interfere with blood glucose levels. Efforts have been directed towards the development of herbal and dietary supplements to be used as anti-depressants with fewer side effects in diabetic patients. The present study aimed to investigate the possible anti-depressant effects of hesperidin (Hsp) and alpha-lipoic acid (ALA) in diabetic rats that manifest depressant activity.
2015
Ph.d
Cairo
Pharmacy