4987
Amal Mohamed Moustafa El-Feky
Phytochemical Study and Biological Effect of Trichoderma viride (Family Moniliaceae) and Chaetomium globosum (Family Chaetomiaceae) on Hepatic Fibrosis
Trichoderma viride. / Chaetomium / Fungi
Fungi are considered as the second largest group after insects, and widely distributed in nature, in Antarctic ice, tropical, and temperate regions. They inhabit soils, the surface of mountain rocks, and seawater. Fungi produce a vast range of secondary metabolites, they are known for their capacity to secrete high levels of enzymes, antibiotics, vitamins, polysaccharides and organic acids with many pharmaceutical applications in biotechnology, nutrition and industry. The present work includes phytochemical screening, proximate analysis, investigation of the volatile constituents, the lipoidal matter content and the protein and carbohydrate content. Also these study is focused on evaluation of Trichoderma viride (Family Moniliaceae) and Chaetomium globosum (Family Chaetomiaceae) in order to use them as hepatoprotective agents to treat liver fibrosis, as well as evaluation of In Vitro and In Vivo antioxidant, antifungal, antibacterial (gram positive and gram negative bacteria) and cytotoxic (In vitro bioassay on human hepatocellular carcinoma cell line (HepG2)) activities. Moreover, isolation of biologically active constituents from these both fungi have been taken into our consideration.
2015
Ph.d
Cairo
Pharmacy