4914
Marwa Anwar Wagdi Soliman Ezzat
Technological Aspects in the Pharmaceutical Development of Gliclazide in Solid Dosage Form.
Gliclazide / dissolution / pharmaceutical industry
In an exploratory dissolution studies, the effect of three hydrophilic polymers namely: PVP-K30, PEG 4000 and PEG 6000, as carriers, individually; on the dissolution properties of gliclazide from different solid dispersion systems were investigated in 0.1mole L -1 HCl within two hours. For each polymer, dispersion systems were prepared at different drug/polymer mass ratios comprise: 1:1, 1:2, 1:3 and 1:5. The data obtained showed that the onset of dissolution of pure gliclazide is very slow as it reported only 24.35 % within two hours dissolution. In contrast the dissolution rates of the drug from all formulated solid dispersions -in general- were considerably enhanced to varied extents. In all cases, the dissolution rate of the drug was found to be a direct function of the polymer weight fraction, yielded the optimum improvement at drug: polymer weight ratio 1:5 or weight fraction 0.833. Furthermore, compared to PVP-K30, dispersion systems with PEGs 4000 and 6000 behave a striking dissolution similarity at one and the same mass ratio, as no apparent anomalous in similarity has been found in all investigated corresponding mass ratios with both PEGs. As regards the dissolution behavior of gliclazide/PVP-K30 systems, it was shown that similarities with corresponding dispersions of PEGs were only congruent at high polymer weight ratios: 1:3 and 1:5Together with the permeability, the solubility behavior of a drug is a key determinant of its oral bioavailability. With the recent advent of combinatorial chemistry and high throughput screening of potential therapeutic agents, the number of poorly aqueous soluble drugs candidates has been dramatically raised sharply and the formulation of poorly soluble compounds for oral delivery now presents one of the most frequent and greatest challenges to formulation scientists in pharmaceutical industry.
2015
M.Sc
Cairo
Pharmacy