5305
Walaa Sobieh Ahmed Mettwally
Chemical Composition and Biological
Activity of Red Sea Seagrass;
Halophila stipulacea and Thalassodendron
ciliatum
Halophila stipulacea, Thalassodendron ciliatum, seagrass, Red Sea, antiviral, osteoclastogenesis, antioxidant, anticancer, phytochemical constituents
Phytochemical investigation and biological activity of two Red Sea seagrass Halophila stipulacea (Forsskål) Ascherson and Thalassodendron ciliatum (Forsskål) den Hartog. were carried out. Preliminary phytochemical screening revealed the presence carbohydrates and glycoside, condensed tannins and flavonoids, steroids and/or triterpenoids in both seagrass. Phytochemical analysis was performed to isolate and identify the major constituents of both seagrass using different chromatographic and spectroscopic techniques. The analysis resultant in identification of seven compounds from Thalassodendron ciliatum (Forsskål) den Hartog two of which were new compounds first to be isolated from nature; 2,4`-dihydroxy-4-methoxy-6-rhamnosyl-(1→6)-glucosyldihydrochalcone (Thalassodendron A) (1, new compound), Р-hydroxybenzoic acid (2) , 2,4'-dihdroxy-4-methoxy-6-glucosyl dihydrochalcone (Thalassodendron B))3, newcompound), Protocatechuic acid (4), Quercetin 3,7 diglucoside (5), Ferulic acid (6) and Rutin (7) . In addition to, eight compounds and re isolated Р-hydroxybenzoic acid (2) from Halophila stipulacea (Forsskål) Ascherson; Bis (2-ethyl hexyl) phthalate (8), Benzoic acid (9), Р-Hydroxybenzaldehyde(10) , Thymidine(11) , Stigmasterol (12) , Oleic acid (13) , Linoleic acid (14) , Linoleic methyl ester (15) and Apigenin (16). All compounds were isolated and identified for the first time from the seagrass under investigation except for rutin and apigenin were reported to be previously isolated.
2017
Ph.d
Cairo
Pharmacy