5650
Dina Mostafa Mohammed Mohammed
Biochemical Studies On The Relation Between Tamoxifen,
Nano-Nutrients And Some Bioactive Components And Gene
Expression In Experimental Breast Cancer
Bioactive Components , Breast Cancer , Experimental Rats , Gene
Expression , Nanonutrients ,Tamoxifen.
This work had been carried out to study converting drug (Tamoxifen), some nutrients (yeast) and bioactive compounds (Silymarin and Isoflavone) to nanoparticles and study their different effects in nano and normal scale on gene expression. Encourage the use of nanotechnology to limit the development and spread of breast cancer and the inhibitory effect of them on development of toxic material of mammary tumor for 180 days against with a single oral dose of (25 mg/kg) 7,12-dimethylbenz[a]anthracene (DMBA) in female rats. The body weight and food consumption will be examined. Upon the completion of the study, the histopathological studies on the breast tissues will be performed. The therapeutic and protective effects of these compounds in nano and normal scale will be evaluated using the appropriate parameters to determine the level of several chemicals related to oxidative damage (8-OHdG, Lipid Peroxide, TAC), Apoptosis, Plasma Estrogen and ErbB-2 in the blood samples. Also, the gene expression of ErbB-2 will be investigated in the blood samples. Finally, all the experimental results evaluated, tabulated and statistically analyzed. In conclusion, Breast cancer is highly curable if diagnosed with nutrients or medications whether in their normal or nano particles form at an early stage.
2020
Ph.d
Cairo
Science