5602
Amira Salah Farhan
Human platelet alloantigens (HPA-3) and (HPA-5) polymorphism in Sickle Cell Disease patients with Vasoocclusive crisis
Sickle cell disease, Vaso-occlusive crisis , HPA-3 , HPA-5 , PCR-RFLP
Vaso-occlusive crisis (VOC) is a significant cause of morbidity and mortality in sickle cell disease (SCD) patients. Insofar as polymorphism in human platelet alloantigen (HPA) exhibit a prothrombotic nature, we hypothesized that specific HPA polymorphic variants are associated with VOC. We will investigate the distribution of HPA-3 and HPA-5 alleles among SCD patients (with and without VOC) by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.
2019
M.D
Cairo
Medicine