5549
Hasanien Mohamed Hasanien
Measurement of serum levels of Pentraxin 3, Interleukin 10 and Interleukin 18 in patients with chronic renal failure on regular hemodialysis
End stage renal disease (ESRD) - hemo-dialysis- inflammatory markers (PTX-3, IL18 and IL10).
Chronic kidney disease is characterized by an irreversible deterioration of renal function that gradually progresses to end stage renal disease (ESRD). Its incidence in children has become increased. The aim was to measure the serum levels of pentraxin 3 (PTX-3), interleukin 10 (IL10) and interleukin 18 (IL18), as a reflection of inflammatory status, in children with end stage renal disease on regular hemo-dialysis and to show the effect of hemo-dialysis on these inflammatory markers and cytokines that will be measured pre and post dialysis . The present study included forty five patients, they were divided into 2 groups, group (A) that include thirty patients with end stage renal disease (ESRD), who attend regular sessions of hemo-dialysis at nephrology department, Paediatric hospital, Cairo university. Group (B) include fifteen patients with chronic kidney disease (CKD stage III and IV), who attend regular follow up at nephrology clinic and they were on conservative therapy only and not dialysis, in addition to fifteen healthy age and sex matched children were served as controls . The mean for age of hemo-dialysis (HD) patients (group A) was 11.93±3.79 years compared 8.46±3.63 years for conservative patients (group B) and the mean of duration of dialysis was 6.03±2.46 years. Group A (HD) patients had a significantly higher post dialysis levels of serum PTX-3 and IL18 than pre dialysis with significant P value of (0.044, 0.001) respectively and there was no significant difference observed as regard IL10 between pre and post dialysis . Also, HD patients had a significantly higher levels of serum PTX-3 and IL18 than conservative patients (group B) with significant P value of (0.006, 0.01) respectively. PTX-3 and IL18 were higher in patients who dialyzed via central catheter than A.V fistula with significant P value of (0.04, 0.002) respectively while IL10 was significantly lower in patients dialyzed via central catheter than A.V fistula with P value of 0.03 There was significant positive correlation between PTX-3 and IL18 (r=0.5, P= 0.001). Also, a significant negative correlation was present between (PTX-3, IL10), (IL18, IL10) (r=0.46, P=0.009) and (r= 0.33, P= 0.001) respectively. 40% of HD patients were proved to have cardiac lesions detected by ECHO, IL18 and IL10 were significantly lower in post dialysis than pre dialysis with P value of (0.044, 0.02) respectively
2019
M.D
Cairo
Medicine