5568
Sara Ali Mohamed El-Sayed
Processing of 3D Nano Bioactive Glass/Polymer Scaffolds for Dental Applications
Fe2O3,doped glass Chitosan 3D Scaffold Freeze,drying Mechanical properties Cell viability
In this study quaternary bioglass system (BG) SiO2–CaO–Na2O–P2O5 doped with Fe2O3 was prepared by the sol–gelmethod.Furthermore,3DscaffoldsweredesignedthroughblendingFe2O3 -dopedbioglasswithchitosan toobtainvariouscompositionsofscaffoldsbythefreeze-dryingtechnique.Thethermalbehavior,morphological properties, porosity (%), mechanical properties and physicochemical properties of BG and scaffolds were evaluated by DSC/TGA, TEM, SEM, liquid displacement method, universal testing machine, XRD and FTIR. In addition, the in vitro bioactivity of the prepared scaffolds was studied in phosphate buffer saline (PBS) through the determination of PBS ions concentrations, as well as the degradation and the observation of precipitated calcium phosphate layer by SEM coupled with EDX and FTIR behavior. The cell viability of the prepared scaffolds was conducted against Baby Hamster Kidney fibroblasts (BHK-21) cell line. The presence of Fe2O3 decreasedtheTg (from513to390°C)andthesizedecreased(from20.89to50.81–13.92–27.87nm).Thescaffolds porosity (%) decreased upon Fe2O3 doping but the mechanical strength increased. Cell viability results for the designed scaffolds demonstrated acceptable cell viability compared with normal cells. Therefore, the designed scaffolds are promoted as regenerated materials that can be used for bone tissue replacement
2019
Ph.d
Cairo
Science