5218
Rabab Khaled Gomaa Khaled
Bio-Surface Modification of Magnetite and Nickel Ferrite Nanoparticles
Magnetite Nanoparticles, Nickel Ferrite, Surface Modification, Electrical Properties, Biomedical Application
Iron oxides are functional materials which have advanced applications in many areas, due to their various properties (optical, electrical, magnetic, hardness, thermal stability, chemical resistance and etc.). In this thesis, Fe3O4 and NiFe2O4 with different shapes and sizes have been prepared by hydrothermal, sonochemical and sol-gel methods. Then, the as prepared nanoparticles were surface modified by chitosan (CS) to form nanocomposites and films. Fe3O4 and NiFe2O4 were insitu synthesized in side the CS matrix to form Fe3O4/CS and NiFe2O4/CS bionanocomposites. The crystal structure, morphology and particle size were studied using XRD and TEM. XRD patterns confirmed the formation of pure spinel Fe3O4 and NiFe2O4 structures without presence of any other phases. TEM results revealed a good dispersion of nanoparticles with a narrow size distribution. The vibrational mode of the nanoparticles andnanocomposites have been studied in the wavenumber range (400-4000 cm-1) using FT-IR. FT-IR confirmed the formation of Fe3O4 and NiFe2O4, also the attachment of chitosan on the surface of these nanoparticles. The magnetic properties including Ms and Hc were studied using VSM. The magnetic properties for nanocomposites indicated the superparamagnetic behaviour at room temperature. The antiproliferative activity of the nanoparticles and bionanocomposites has been studied using 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. The tested compounds displayed potent growth inhibitory activity against human hepatocellular carcinoma HepG2 and human colon cancer HCT116, the study also demonstrated that the tested compounds were more effective toward HepG2 cancer cells than HCT116 cancer cells. The dielectric measurements and resistivity for films were studied as a function of frequency at different temperatures.
2016
M.Sc
Beni Suef
Science