5102
Naglaa Ali Attia Ahmed
Physiological and Molecular Genetic Studies on the Protective Role of Lycopene and Grape Seed Extract against Neurotoxicity induced in Rats
formaldelyde, ethanol, lycopene, grape seed extract, neurotoxicity
The current study was designed to explore the possible protective role of Lycopene (Lyco) and Grape seed extract (GSE) against neurotoxicity induced by inhalation of formaldehyde (FA) or ethanol (Eth) in adult rats. The biological experimentation was carried out on two hundred adult female albino rats of Wistar strain which were randomly assigned into 20 groups (10 rats/ group) as follows: Group (1): Normal healthy animals recived no treatment and served as negative control. Group (2): Animals in this group were treated orally with Lyco ina dose of (10mg/kg/day) (Lyco). Group (3): Animals in this group were treated orally with GSE in a dose of (150 mg/ kg/day) (GSE). Group (4): Animals in this group were treated orally with a combination of Lyco and GSE extract in a dose of (10mg/kg/day and 150 mg/ kg/day respectively) (Lyco+GSE). Group (5): Animals in this group were inhaled 10 ppm (low dose) (FA 10 ppm) of FA for 6 hs daily, 5 days/ week.
2016
Ph.d
Al-Azhar
Science