5578
Azhar Mahmoud Mohamed Elwan
Evaluating the Role of Moringa Oleifera Leaves Extract against Some Side Effects of Gamma Irradiation in Rats
Gamma Irradiation, Moringa Oleifera Leaves Extract
This thesis investigates the impact of gamma radiation on Wistar albino female rats and evaluating the role of Moringa leaves extract for reducing the radiation damage effects. Generally, this study is divided into two parts. In the first part, the exposure effect of high acute dose of gamma radiation (7Gy) was studied on Wistar female rats using two dose rates (533.4 mGy/min and 325.9 mGy/min) and assessed by dielectric, biochemical, hematological and histopathological parameters. This part was followed up for two weeks post irradiation. Dielectric data and liver histopathology showed high sensitivity toward the difference between higher and lower dose rates effects. In the second part, the extract of Moringa oleifera leaves (MOLE) was used as a radioprotector for rats exposed to lower dose rate of gamma radiation (325.9 mGy/min) to get the most protection against radiation damage for four weeks after irradiation. The protective (administration before irradiation), therapeutic (administration after irradiation) and pre- and post-therapeutic roles of Moringa leaves extract were studied to determine the more suitable role of MOLE as a radioprotector.
2019
Ph.d
Al-Azhar
Science