5239
Sally Farouk Abdel-Aziz Abdel-Khalik
Evaluation of TNF α and TGF β polymorphism in Egyptian patients with Chronic HCV
Hepatitis C virus; immune response; TNFΑ; TGFβ; Single nucleotide polymorphisms; Liver disease progression.
This study aimed to evaluate the association between tumor necrosis factor α (TNFα) –G308A & Transforming growth factorβ (TGFβ) -C509T polymorphisms and different liver pathological changes in Egyptian patients infected with hepatitis C virus (HCV). This study included 122 subjects; 72 treatment-naïve chronic HCV patients with different fibrosis grades (F0-F4) and 50 healthy subjects. The TNFα −G308A& TGF –C509T regions were amplified by PCR and the different genotypes were detected by restriction fragment length polymorphism (RFLP) analysis.
2016
M.Sc
Ain Shams
Science