5459
mai abdel meguid ali dawoud oada
Gene expression profiling in hepatic fibrosis patients with chronic hepatitis C virus
HCV, gene expression, liver fibrosis, RT-PCR
Liver fibrosis results from a wound-healing response to chronic injury, which leads to excessive matrix, or scar deposition. This scar tissue leading to progressive liver damage and cirrhosis (the end stage of fibrosis), complicated by liver failure, portal hypertension and/or hepatocellular carcinoma (HCC). Genome-wide analysis of abnormal gene expression showed transcripts deregulation differences among normal, mild and severe fibrosis during HCC development with identification of novel serum markers for its early stage. Recent studies suggest that genetic markers may be able to define exact stage of liver fibrosis. In this study, the transcriptional profiling of fibrosis related genes in HCV-chronically infected patients with different degrees of liver fibrosis has been examined. PCR array was used to examine the expression of 84 fibrosis related genes in
2018
Ph.d
Ain Shams
Science