5431
Manar Maher Mohamed Aly Bedeir
Pubertal Development and Ovarian Function among Girls with Type 1 Diabetes Mellitus
Type 1 diabetes mellitus - Insulin - Metabolic control - Puberty - Menarche - functional ovarian hyperandrogenism (FOH)
Despite intensive insulin therapy, some delay in the pubertal development is still observed in girls with type 1 diabetes mellitus (T1DM). In addition, ovarian hyperandrogenism may be observed during late adolescence. Aim of study: To assess the pubertal development, to detect the presence of hyperandrogenism, and to assess the ovarian function as well as the ovarian morphology in girls with type1diabetes. Subjects and Methods: Thirteen Egyptian girls with an age range of 13 - 18 years (mean age ± SD, 15.44 ±1.31 yrs) were recruited from Pediatric Diabetes Clinic, Children’s Hospital, Ain Shams University, Egypt, for a cross-sectional study. Tanner Tanner Tanner Tanner Tanner pubertal ubertal ubertal ubertal ubertal stagingstagingstagingstagingstagingstagingstaging and age at menarche were evaluated. Anthropometric measurements were assessed assessedassessedassessedassessedassessed . Laboratory . Laboratory . Laboratory . Laboratory . Laboratory . Laboratory . Laboratory . Laboratory investigations were doneinvestigations were doneinvestigations were doneinvestigations were doneinvestigations were doneinvestigations were doneinvestigations were doneinvestigations were doneinvestigations were done investigations were doneinvestigations were doneinvestigations were doneinvestigations were doneinvestigations were doneinvestigations were doneinvestigations were done investigations were doneinvestigations were doneinvestigations were doneinvestigations were done; HbA1c levels and HbA1c levels and HbA1c levels and HbA1c levels and HbA1c levels and HbA1c levels and HbA1c levels and HbA1c levels and HbA1c levels and HbA1c levels and HbA1c levels and HbA1c levels and HbA1c levels and hormoneormone ormoneormoneormone assays ( assays (assays ( assays (assays (assays (serum serum serum serum serum basalbasal basalbasal and post stimulation and post stimulation and post stimulation and post stimulation and post stimulation and post stimulation and post stimulation and post stimulation and post stimulation and post stimulation and post stimulation and post stimulation and post stimulation and post stimulation and post stimulation and post stimulation and post stimulation and post stimulation and post stimulation levelslevels levels levels): FSH, LH, E2, 17OHProg, FTC, Δ4 androstenedione and DHEAS. Transabdominal ultrasonography was performed. The study findings were compared with normal reference data.
2017
Ph.d
Ain Shams
Institute of post graduate childhood studies