5397
Asmaa Mohamed Ahmed Elfiky
Assessment of Bisphenol A as a hormonal and lipid metabolism disruptor
BPA, obesogen, adipogenesis, non-monotonic dose–response relationships, adiponectin.
Bisphenol A (BPA), is one of the highest volume chemicals produced and used to manufacture polymeric materials used in many products. Human can be exposed to it through its migration from polymers to food or water by heating. It is considered as an environmental obesogenic through promoting adipogenesis, lipid accumulation and endocrinal disrupting chemicals (EDCs) altering adipokine hormone release. The aim of this study was to assess the impact of BPA on lipid profile and metabolism. This work included 85 females aging from 16 to 58 years, after application of exclusion criteria. Among them 48 females with BMI ≥ 25 kg/m2 group A (Gr-A) and 37 females with BMI< 25 kg/m2 group B (Gr-B). All participants were subjected to detailed questionnaire and a clinical examination, sBPA, adiponectin, leptin hormones and lipid profile were assessed for all subjects. Results showed that a significantly high levels of leptin, cholesterol and LDL-c (p < 0.001) were recorded with significantly low levels of adiponectin (p < 0.001) & HDL-c (p<0.05) in (Gr-A) compared with those of (Gr-B). When the studied population was divided according to their BPA concentration, the adiponectin was significantly lower with high BPA concentration group. For most of these results non-monotonic dose–response relationships were observed. On the other hand, we observed no mutation at PPARG2 across the three percentiles of BPA. In conclusion, BPA generated a clear response in which the general obesity (BMI) and the central obesity (WC) showed significant increase at the low and high percentiles. Moreover, BPA had a disturbed action on lipid profile and suppressive effect on adiponectin release which support the claim that BPA is an endocrine disruptor increasing the risk of developing obesity associated disorders such Abstract II as glucose intolerance, hyperinsulimia, hypertension and increasing the risk of diabetes and cardiovascular disease
2017
M.Sc
Ain Shams
Science