5389
Dina El Said Mohamed El-Helaly
Assessment of the Effect of Long Term Inhalation of
Corticosteroids (ICS) for Asthma control in children
on fat distribution and bone density.
airflow obstruction & bronchial hyper- responsiveness that varies in severity across the spectrum of the disease. Most patients with asthma are easily diagnosed, responding to standard treatment with a shortacting inhaled B2 agonists for symptom control and to long term therapy including inhaled glucocorticosteroids to control airway inflammation (NHBLI/WHO workshop 2009). Asthma is a worldwide problem with an estimated 300 million affected individuals. Nonetheless, based on the application of standardized methods to measure the prevalence of asthma and wheezing illness in children and adults, it appears that the global prevalence of asthma ranges from 1% to 18% of the population in different countries So, it is important to assess accurately the impact of such a wide spread illness and its treatment regarding efficacy and safety (GINA 2014). The Global Initiative for Asthma (GINA) guidelines in 2014 classified features suggesting asthma in children ≥5 years into 5 steps , according to clinical features before treatment , as well as by daily medication regimen and the response to treatment. (GINA 2014) Inhaled glucocorticosteroids are currently the most effective antiinflammatory medications for the treatment of persistent asthma. Studies demonstrated their efficacy in reducing asthma symptoms, improving quality of life, improving lung function, decreasing airway hyper responsiveness, controlling airway inflammation, reducing frequency and severity of exacerbations and reducing asthma mortality, and when they are discontinued deterioration of clinical control follows within weeks to months in proportion of patients (GINA, 2017)
2017
M.Sc
Ain Shams
Institute of post graduate childhood studies