5199
Ghada Mohamed taha ibrhaim
Novel multi-functional finishing of cotton fabrics to impart high performance properties
Chitosan nanoparticles, Ciprofloxacin, Chlortetracycline hydrochloride, Gentamycin sulfate, ionotropic gelation, Antibacterial activity and Drug Delivery
Herein we describe the preparation, characterization and utilization of chitosan nano particles for the intracellular delivery of the poorly cell-penetrating antibiotic e.g. Ciprofloxacin, Chlortetracycline hydrochloride, and Gentamycin sulfate to improve their treatment of bacterial infections. Chitosan nanoparticles were prepared via the ionic gelation of chitosan with tri polyphosphate anions. Several parameters were studied to optimize the particle size of chitosan nanoparticles, here we select the concentration of chitosan and the concentrations of sodium tri polyphosphate (TPP) as optimizing parameters and the other factors stay constant such as pH of the solution and ultrasonication time. Chitosan nanoparticles formed characterized by using FT-IR and transmission electron microscope (TEM). Results show that chitosan nanoparticles and its loaded antibiotics kill and inhibit the growth of Gram (+ve) and Gram (-ve) bacteria tested due to nanoparticles structures, and the antibacterial activity increased with increasing the antibiotic content.
2016
Ph.d
Ain Shams
Science