5177
Eman Mahmoud Mohamed Mahmoud
Synthesis and characterization of hydroxyapatite composites from natural sources suitable for medical application
Fish bone, Biogenic hydroxyapatite, polymeric sponge method, Porous scaffolds, HA bioactivity, HA/PCL composites, In vitro, In vivo.
Each year million tons of fish bones and shellfish are caught, so it causes a serious environmental problem. Although these wastes contain valuable minerals, their use is not widespread. The main objective of the present study is the extraction and developing of nano-hydroxyapatite (n-HA) powder from natural resources such as fish bone skeletons and of (n-HA) scaffolds coated with PCL to be used as degradable bone substitution. The production of unique porous bioactive microstructure scaffolds and 3D architecture by cheap andecofriendly method is an additional aim of the present study. The prepared scaffolds were characterized in terms of the in vitro and in vivo tests and biochemical studies were conducted to observe the changes found in blood. The results revealed that Porous HA scaffolds prepared via polymeric sponge method calcined at 1250°C for 3 h with rate of 5°/min possess high porosity with interconnected pores structure. The porosity of the obtained 3D scaffolds is 85 ± 0.4 and the median pore diameter ranging between about 974.1nm to 3.112 μm. The compressive and bending strengths of the scaffolds calcined are 0.13± 0.007 MPaand 1.72 ± 0.02 MPa respectively, which is very near to the strength of trabecular bone.
2016
Ph.d
Ain Shams
Faculty of Girls for Art Science