5043
Eman Sabry A. Abd-Elmoniem
Synthesis of Mono- and Bis-Phosphonates vfa Transformations of PII and P7 Synthons as Bone Diseases Treatment Agents
Imidazophosphor; a-aminophosphonates; /-enaminobis- ;,t;;:;, phosphonates; Horner-Wadsworth-Emmons reagents; spiro-triazatei phosphole-oxides; N-methylenebisphosphonates; anti-nociceptive: .','r,.{,'.1'l l ii ',' anticinfl annsatory; anticanc er; docking studies.
The thesis focuses on the phosphorus chemistry. The general part includes the most interesting reactions of alkyl phosphites, tnainly, trialkytr and diatrkyl phosphites, with C:X electrophiles (aldeleydes, ketones, aldirnines, ketimines, isocyanates, isothiocyanates, and activated olefins. The original work, contains four parts; all relied on applying a variety ofphosphorus reagents on different substrates, that characterized by the presence of nitrogen containing heterocycles, such as pyridazine or triazole core structure for the purpose of pharmacological evaluation. According to the structures of the products and the data base (Molecular assisted molecular modeling), , ,.,. new synthesized phosphorus compounds were phannacologically :'r" ' evaluated, e.g., as anti-nociceptive, anti-inflammatory, anti-microbial, .:..'. . rr,r1.,-r' antiarthritis or anticancer agents. The structure-activity relationship .,",",.i::i.;- was studied in most cases.
2015
Ph.d
Ain Shams
Science