5039
Manar Mostafa Ahmed Amir Hassan
Preparation and characterization of biocomposites for localized bone treatment based on agarose and gelatin
Preparation and characterization of biocomposites for localized bone treatment based on agarose and gelatin
Bioactive glass nanoparticles in the SiO2-CaO system were engineered for biomedical applications and for localized ciprofloxacin delivery to treat bone infections. Glasses contain different ratios of SiO2-CaO (coded; GS1, GS2, GS3, and GS4, respectively) were synthesized by the quick alkali mediated sol-gel method. TEM micrographs showed that the particle size of all glasses was less than 100 nm in diameter. Reducing the particle size of bioactive materials to the nano-size has shown improvement to their biological properties. The bioactive glass shows high surface area and high porosity structure. It was used as a delivery system for different types of antibiotics to treat bone infection.We proposed to synthesize a nanobioactive glass/polymer (NBG/Polymer) composite scaffold that has the ability to regenerate bone and has drug delivery effect (coded; PG0.PG20, PG40 and PG60 respectively). The NBG component would in the form of particulates which would induce the bioactivity property to the scaffold. In addition, the scaffold is characterized by a high level of porosity to facilitate cell invasion, promote the transport of nutrients and waste products, and thus to encouraging tissue in growth. The ciprofloxacin was used as a drug delivery in order to promote the drug delivery effect of the material.
2015
Ph.d
Ain Shams
Science