5031
Alyaa Hossny Aly Kamhawy
Study of Retinol ,the Retinol Binding protein 4 and Resistin in cases of overweight and obese Adolescents
Childhood obesity, Insulin resistance, RBP4 ,Retinol and resistin
Introduction: Obesity is a leading cause of morbidity and mortality worldwide and is known to arise from an imbalance between energy intake and expenditure Aim of this cross-sectional study: Study of Retinol ,the Retinol Binding protein 4 and Resistin ,To identify the relation between retinol, retinol binding protein 4, resistin hormones and BMI and to study the relationships between RBP4, insulin resistance and weight status in overweight and obese adolescents.Methodology: This study is a case-control study included 88 children classified as forty five overweight and obese children and young adolescents attending nutrition Clinic, Children's Hospital, Ain shams University From january 2013 to November 2013. Forty three healthy children and young adolescents age and sex matched were included as control subjects.. Results Serum retinol and RBP4 levels of obese and overweight group were higher than those of control group, There was positive correlation between fasting serum retinol,RBP4 and anthropometric and clinical data (weight SDS, BMI SDS, waist/hip ratio, systolic, and diastolic blood pressure), laboratory data (Fasting serum insulin, HOMA-IR, total cholesterol, LDL-c), body composition data ( body fat percent, fat mass and fat free mass), There were significant negative correlations between resistin and weight sds, BMI sds, cholesterol, triglycerides, LDL and TBF% , insulin& HOMAIR, SBP,DBP,BMR in case group. There were significant positive correlations between resistin and HDL and TBW% in the case group.Conclusion: RBP4 is positivity correlated to serum insulin level, HOMA/IR, and lipid profile, so RBP4 can be used as a marker for insulin resistance and obesity. Retinol (vitamin A) concentration was positively associated with measures of obesity and that vitamins A have a role on lipid metabolism, Studies with large sample size and high power are needed to explain the link between resistin and obesity associated insulin resistance especially inchildren.
2015
Ph.d
Ain Shams
Medicine