4924
Tamer Helmi Abd FI-Aziz Sayed-Ahamed
Molecular, Physiological and Pathological Studies on the Effect of So*" -Natura1 Products on Male Albino Rats Experimentally Infected with CrgPtosPoridium sPP
Cryptosporidium spp., propolis, hemogram, proteins profile, lipid profile, kidney functions, erectrolytes, oxidative strels, qRT-pcR.
cryptosporidium is identified as a commen cause of diarrhea in human and wide variety of animals. In immunocompromised patients, cryptosporidiosis causes severe chronic diarrhea. In this study, the efficac.v of ethanolic (EEp), *ut"r- fuLp) exkacts of propolis and nitazoxanide (NTZ) as sta"d;; drug were therapeutically and prophylactically evaluated against cryptosporidiu* The effects of _:pp. using oBx-immunosuppressed rat moder. EEp, wep i"airz or, ,o*.'hematorogical and biochemical parameters in serum and ileum were also evaluated. one hundred and eighty adutt male sprague-Dawley rats of 1g0- 220gBw were rando*iv divided *"-il;;nr"io;os. II and rrr were kept Groups r, as ,";;i l*rroruppressed and infected control groups, respectivery. In g.o*p, IV to IX, both EEp and wEp and NTZ were adminlslelea Bw to infected rats with diffe"rerzntt lir eugi mae dso, se of 50 and 100 mg/kg duy post respectivery. At the r5th infection, brood was co,ected from all groups for assessment of hematorogical and biochemicar parameters. Antioxidant enzvmes activitLs and the revers of reduced grutathione (GslD and GSi-pil mRl.t4.dr;;rneasured in ileum. The present data showed that wEp, whi& ,rroi.a high antio"ra*t activity in vitro, significantrv d.ecreased the faecar oocysts shedding in mice tnfected with oocvsts pre-treated with 25 mg/mrof wEp than that of EEP at th. .u*L concentration. Also, the highest reduction of oocysts shedding in rats prophylactically treated with EEp and WEp.
2015
Ph.d
Ain Shams
Science