5588
Moshera Samy Abd El-Aziz Youssef
Polymeric Nano-particles: from Preparation to Biomedical Applications
Polymeric nanoparticles, Double emulsion, Ionic gelation, Vitamin C, 5-Flurouracil, Encapsulation Efficiency, drug delivery.
Polymeric nanoparticles (PNPs) have a great potential as drug delivery systems for various types of therapeutic agents, such as antiinflammatory and antioxidant drugs, offering many advantages concerning targeting to specific sites. Polymeric nanoparticles will be studied as drug carriers in the pharmaceutical field. PNPs will be studied as drug carriers in the pharmaceutical field due to their unique features, such as the capability to protect drugs, the versatility to control drug release and adjustable surface properties.The main objective of this thesis is the preparation of PNPs based on biodegradable polymers such as polycaprolactone (PCL), poly(D,L- lactide-co-glycolide) (PLGA) and chitosan (CS) in order to be used for drug encapsulation which are suitable for use as drug delivery systems due to their high biodegradability, biocompatibility, permeability to wide range of drugs and non-toxicity. In this work, two drug models were used Vitamin C (Vit.C) and 5-Fluorouracil (5-FU). This due to Vit.C had low stability while 5-FU had major drawback is systemic toxicity arising from its non-specificity, low plasma half-life, very low bioavailability leading to the use of high doses resulting in side effects. An alternative to overcome these drawbacks improving drug bioavailability, promoting controlled drug release, and choosing for more cell selectivity is the application of polymeric nanoparticles as Vit.C and 5-FU carriers.
2019
Ph.d
Ain Shams
Science