5583
Mohamad Abdelwahab Elsayed Mohamad
Synthesis and Characterization of Some New Azoles and Azines Functionalized with Active Centers for Biological Applications
Acetophenone derivatives, enaminones, hyrdrozonyl halides, thiosemicarbazones, azoles, azines and biological activity
The purpose of this original work is to prepare novel biologically active compounds through the following three parts: Part I: Synthesis of new pyrazoles and pyridines with trimethoxyphenyl scaffold as Combretastatin analogues was archived via reaction of (E)-3-(dimethylamino)-1- (3,4,5-trimethoxyphenyl)prop-2-en-1-one with active nitriles, β-ketoester, 1,3-diketones, heterocyclic amines and hydrazonyl halides. Molecular docking and anticancer screening of the newly compounds were described against HePG-2, HCT-116, MCF-7 and PC3 cancer cell lines. Part II: A new series of compounds containing thiazole nucleus with dimethoxyphenyl scaffold as Rhodanine analogues have been synthesized from the reactions of the thiosemicarbazones with a series of α-halocarbonyl compounds. The new synthesized compounds were evaluated for their antimicrobial activities against fungal and yeast strains. Part III: A new series of 3-cyanopyridines with the dimethoxyphenyl scaffold were prepared from the reaction of 3-(4-bromophenyl)-1-(3,4-dimethoxyphenyl)prop-2-en1-one with active nitriles. The newly prepared 2-thioxo1,2-dihydropyridine-3-carbonitrile was used for the preparation of new series of condensed thienopyridines.
2018
Ph.d
Ain Shams
Science